Contact portal dmw fulltext search fulltext search. Pode ser esporadico ou associado a sindrome da neoplasia endocrina multipla tipo 1. About 25 to 30 percent of gastrinomas are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 men1. Zollingerellison syndrome is a rare disorder that occurs when one or more tumors form in the pancreas and duodenum.
Type ii lesions are caused by gastrinomas gastrinproducing tumors, also known as zollinger ellison syndrome. Experts do not know the exact cause of zollingerellison syndrome. Zollingerellison syndrome zes is caused by a nonbeta islet cell, gastrinsecreting tumor of the pancreas that stimulates the acidsecreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration. The zollinger ellison syndrome zes is a pathology caused by a neuroendocrine tumor, usually located in the pancreas or the duodenum, which is characterized by elevated levels of gastrin, resulting in an excessive production of gastric acid. Value of surgery in patients with negative imaging and sporadic zollinger ellison syndrome. Zollinger ellison zes syndrome is characterized by gastric acid hypersecretion resulting in severe acidrelated peptic disease and diarrhea. The role of gastrin in causing the hyperplasia is discussed since in the zollinger ellison syndrome it is formed ectopically in very large amounts. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the zollinger ellison syndrome. Request pdf on jan 1, 2012, volker fendrich and others published surgical treatment of zollingerellison syndrome find, read and cite all the research you need on researchgate. Zollingerellison syndrome zes is an endocrinopathy characterized by gastrinsecreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Surgical treatment of zollingerellison syndrome request pdf. See management and prognosis of the zollinger ellison syndrome gastrinoma.